|
KMID : 1137820150360060291
|
|
의공학회지
2015 Volume.36 No. 6 p.291 ~ p.295
|
|
|
Studies on Osmotically Driven Drug Infusion Pump Under the Change in Body-Simulating Environment
|
|
Yoon Chul-Whan
Ahn Jae-Hong
Park Doh
Lee Jae-Yeon
Park Chun-Gwon
Park MIn
Choi Young-Bin
|
|
|
Abstract
|
|
|
|
Various types of implantable drug delivery devices have attracted significant attention for several decades to improve drug bioavailability and reduce side effects, thus enhancing therapeutic efficacy and patients’ compliance. However, when implanted into the body, the devices may be influenced by the changes in physiological condition, such as temperature, pH or ionic concentration. Thus, the drug release rates could be also altered concurrently. Therefore, in this work, we employed an implantable ALZET Osmotic Pump, which has been widely used to locally deliver various therapeutic agents and examined the effect of pH, temperature and ionic concentration on its drug release rate. For this, we performed in vitro cell tests to simulate the condition of local tissues influenced by the altered drug release rates, where we used diclofenac sodium as a model drug.
|
|
|
KEYWORD
|
|
|
drug delivery, osmotic pump, pH, temperature, ionic concentration
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|